ITP
ITP Treatment in Kolkata
Symptoms of ITP
- Easy bruising
- Tiny reddish-purple spots (petechiae) on the skin, particularly on the lower legs
- Larger skin bleeding or discolorations, known as Purpura
- Gum or nose bleeding
- Unusual blood presence in urine or stool
- Excessive menstrual flow
Causes of ITP
- Medications that may trigger an allergic reaction related to platelets.
- Infections, such as chickenpox, hepatitis C, or HIV.
- Pregnancy-related immune changes
- Autoimmune disorders like lupus or rheumatoid arthritis.
- Certain types of cancer, including low-grade lymphomas and leukemias.
In children, ITP occurs due to viral infections like mumps or the flu, while in adults, bacterial infections such as H. pylori may play a role.
Types of ITP
ITP is classified into two categories based on age group, duration, and underlying causes. Below are the two types of ITP:Acute ITP
Acute ITP is short-lived and most commonly affects children. It often develops after a viral infection, such as the flu or mumps.
Characteristics:
- Sudden onset of low platelet count
- Often follows a viral infection
- Generally self-limiting
- Automatic recovery is common.
- Usually, less or minimal medical intervention is required.
Age Group:
Mostly affects children between 2-6 years
Duration:
Typically lasts less than six months
Prognosis
Approximately 80-90% of children recover from acute ITP automatically, without long-term complications
Chronic ITP
Chronic ITP is a severe form of the condition, more often observed in adults. Unlike acute ITP, it does not cure on its own.Characteristics:
- Gradual onset of symptoms.
- Episodes of low platelet count that recur or stay despite treatment.
- Higher risk of bleeding complications
- Can affect both children and adults
Duration:
Lasts six months or longer.Prognosis:
Management focuses on controlling symptoms and preventing complications. Treatments may include medications, lifestyle changes, or splenectomy in severe cases.Primary ITP
Primary ITP occurs as an isolated condition without an associated underlying disorder.Cause:
Immune system dysfunction directly targets platelets.Management:
Treatment focuses on concealing the immune response and increasing platelet count.Secondary ITP
Secondary ITP occurs as a result of other conditions or factors.
Common Causes:
- Autoimmune diseases like lupus or rheumatoid arthritis.
- Viral infections such as hepatitis C, HIV, or H. pylori.
- Certain medications influence an immune response affecting platelets.
Management:
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Diagnosis of ITP
- Screening medical history and physical examination to check bleeding history and symptoms.
- Blood tests for platelet count and other blood components.
- Bone Marrow test when other conditions need to be ruled out.
Treatment of Immune Thrombocytopenia (ITP)
Medicinal Therapies
Steroids:
These medications suppress the immune system’s activity to slow down platelet destruction. Steroids like prednisone are often the first line of treatment for ITP.
Intravenous Immune Globulin (IVIG):
Administered to boost platelet count temporarily.
Platelet-Stimulating Drugs:
Medications such as eltrombopag and romiplostim help increase platelet production in the bone marrow.
Other Drugs:
For patients unresponsive to first-line treatments, options like rituximab may be recommended.
Surgery
For chronic ITP cases, removing the spleen (splenectomy) might be suggested to reduce platelet destruction.